Kirke is the only addition to the 17 that who emerged victorious at Odsal with Lee Smith and Carl Ablett making way from the initial 20 players named.
Wigan coach Brian Noble will be hoping for a response from his side as they confront another testing away trip.
The Warriors lost a sixth successive game to near neighbours St Helens on Good Friday and will be hoping for a return to winning ways at Headingley.
Noble has named an unchanged squad from the defeat at Knowsley Road with Darrell Goulding and Danny Hill the men to drop out of the original 20-man squad.
Leeds: Webb, Donald, Toopi, Senior, McGuire, Burrow, Leuluai, Diskin, Peacock, Jones-Buchanan, Ellis, Sinfield, Lauitiiti, Thackray, Bailey, Kirke, Gibson, Tansey
Wigan: Ashton, Calderwood, Bailey, Richards, Barrett, Leuluai, Fielden, Higham, Paleaaesina, Hock, Fletcher, O'Loughlin, Vaealiki, Millard, Prescott, Hansen, Goulding, Hill, O'Carroll